Research in QTL Analysis Searching for QTL in designed experiments
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چکیده
Designed experiments are employed to guarantee linkage disequilibrium between the genetic markers and the QTL, and also to limit the number of possible alleles segregating at a QTL. Many QTL studies in domestic livestock have used wide crosses, involving an economically relevant breed and a distantly related economically irrelevant breed. Alternatively, a number of large paternal halfsib families can be generated from existing outcrossed populations. The latter design carries less risk of producing results that are irrelevant to commercial breeding populations.
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